Ten more NFL games are set for Sunday afternoon either in the 1 p.m. ET or 4:05/4:25 p.m. ET window, and those matchups comprise the main slate for NFL DFS sites like FanDuel and DraftKings. One of the early kickoffs — Bills vs. Dolphins — has the highest over/under (50) for the week, so that game should be a focus for NFL daily Fantasy players with big names like Josh Allen, De’Von Achane and James Cook in action. Other big names expected to be playing on the main slate include Lamar Jackson, Justin Jefferson, Breece Hall and Kyren Williams.
How should they factor into your NFL DFS picks this week, and who are the sleepers in the NFL DFS player pool that can help differentiate your lineups? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS lineup optimizer.
New users can also target the latest Underdog promo code, where they can pick at Underdog and get $100 in site credits after making a $5 wager:
The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 10 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.
New users can get $50 in Pick6 credits at DraftKings when they play $5.
Top NFL Week 10 DFS picks for Sunday
One of the optimizer’s top DFS value picks for Sunday is Detroit Lions quarterback Jared Goff at $5,900 on DraftKings and $7,800 on FanDuel. Goff is averaging nearly 240 passing yards per week, and has only had fewer than 200 yards one time this season, giving him a high floor. He’s also thrown 17 touchdowns against the just three interceptions. The Lions face the Commanders, a team that has given up the fifth-most Fantasy points to opposing quarterbacks. See who else to pick here.
The optimizer’s NFL DFS strategy also includes building around Carolina running back Rico Dowdle at $8,000 on FanDuel and $6,300 on DraftKings. Since taking over the starting job in Carolina in Week 5, Dowdle has been one of the league’s best backs. He’s rushed for 652 yards and three touchdowns in that span, while adding 10 catches and a receiving touchdown. He faces the Saints, who have given up the 22nd most Fantasy points to opposing running backs. You can see the rest of the optimizer’s NFL DFS picks here.
New users can also check out the latest FanDuel promo code and get $150 in bonus bets at FanDuel if your $5 bet wins.
How to build Sunday Week 10 NFL DFS lineups
The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer’s NFL DFS picks, at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.
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